I-3D bioprinting iyinkundla yokukhiqiza ethuthuke kakhulu engasetshenziswa ukuphrinta izicubu ezivela kumaseli futhi ekugcineni izitho ezibalulekile.Lokhu kungavula imihlaba emisha kwezokwelapha kuyilapho kuzuza ngokuqondile iziguli ezidinga ukushintshwa kwezitho zomzimba.
Esikhundleni sokulinda umnikezeli ofanelekayo noma ukubeka umzimba engozini ngokwenqaba isitho esitshalwe kabusha, iziguli zinezitho zangokwezifiso ezakhelwe injongo ukuze zithathele indawo ekhubazekile.Kodwa-ke, ngisho nentuthuko ye-3D bioprinting kule minyaka engu-20 edlule, isantula inqubekelaphambili ebalulekile ukuze kukhiqizwe ukwakhiwa kwezicubu ze-biomimetic eziyinkimbinkimbi ze-3D.
Ngokusho kwabacwaningi baseSingapore University of Technology and Design (SUTD), iNanyang Technological University (NTU) kanye ne-Asia University, ubuchwepheshe besiko lezicubu ikakhulukazi budinga ukusheshiswa ukuze kubhekwane nebhodlela ekuvuthweni kwezicubu ze-3D ze-bioprinted multicellular ezakha izicubu ezisebenzayo.Iphepha labo locwaningo, elinesihloko esithi “Ngiphrinte isitho!Kungani singakafiki?”ishicilelwe ku-Advances in Polymer Science.
Kuleli phepha, abacwaningi baphinde banikeze ukubuyekezwa okujulile kwentuthuko yakamuva futhi bahlaziye ubuchwepheshe be-bioprinting.Inqubekelaphambili ekuthuthukisweni kwe-bioink, ukuqaliswa kwe-bioprinting entsha kanye namasu okuvuthwa kwezicubu nakho kuyahlaziywa.Kuphinde kuqashelwe indima yesayensi ye-polymer nokuthi ihambisana kanjani ne-3D bioprinting ukuze kunqotshwe ezinye zezithiyo ezinkulu emkhakheni wokuphrinta isitho, njengokuvumela i-biomimetic, i-angiogenesis kanye nezakhiwo zebhayoloji ezihlobene ne-3D (njengoba izithombe ezingezansi zibonisa ).
Ukusetshenziswa kwamasu ahambisanayo, njengezinhlelo eziguquguqukayo ze-co-culture perfusion, kuthathwa njengokubalulekile ukuze kuqinisekiswe ukuvuthwa nokuhlanganiswa kokwakhiwa kwezicubu ze-bioprinted.Ngisho noma manje kungenzeka ukukhiqiza izicubu ezisezingeni lomuntu noma izitho ezingase zivuthwe zibe yizicubu ezine-vascularized nezisebenza ngokwengxenye, imboni isasele ngemuva ekunyathelisweni kwezicubu eziqondene nomuntu noma izitho ezithile ngenxa yobunkimbinkimbi be-matrix engaphandle kwezicubu ezithize. I-ECM) kanye nenqubo yokuvuthwa kwezicubu - ukuntuleka kwemidiya ye-co-culture efanelekile ukusekela izinhlobo zamaseli amaningi futhi kudinga ukulungiswa okwengeziwe kwezicubu ngaphambi kokufakwa.
“Nakuba i-3D bioprinting isesigabeni sayo sokuqala, ukugxuma okuphawulekayo eyenzile eminyakeni yamuva nje iphakamisa iqiniso eliphelele lezitho ezisebenza elebhu.Kodwa-ke, ukuze siphushe imingcele yemithi, kufanele sinqobe izinselele zobuchwepheshe zokwenza izicubu.Ama-bioink athile awayithuthukisi inqubo yokuvuthwa kwezicubu.Lokhu ekugcineni kuzoba nomthelela omkhulu ezimpilweni zeziguli, eziningi zazo ezingancika ekusaseni le-3D bioprinting,” kusho uSolwazi Chua Chee Kai, umbhali oholayo wephepha.
Isengezo se-JSIsevisi yokuphrinta ye-3D nayo ibilokhu ithuthukisa futhi ithuthuka, efinyelela izinga elithuthuke kakhulu embonini yezokwelapha ukuze ihlangabezane nezidingo zeziguli ezinkulu kanye nocwaningo lwesayensi.Amamodeli ethu ezokwelapha aphrintiwe e-3D nemikhiqizo eqediwe nayo isetshenziswa kabanzi ezinhlelweni zaphesheya kwezilwandle.Siyakwamukela futhi usebenzise.
