I-3D bioprinting iyinkundla yokukhiqiza ethuthuke kakhulu engasetshenziswa ukuphrinta izicubu kumaseli futhi ekugcineni izitho ezibalulekile. Lokhu kungavula imihlaba emisha kwezokwelapha kuyilapho kuzuza ngokuqondile iziguli ezidinga ukushintshwa kwezitho zomzimba.
Esikhundleni sokulinda umnikezeli ofanelekayo noma ukubeka umzimba engozini ngokwenqaba isitho esitshalwe kabusha, iziguli zinezitho zangokwezifiso ezakhelwe injongo ukuze zithathele indawo ekhubazekile. Kodwa-ke, ngisho nentuthuko ye-3D bioprinting kule minyaka engu-20 edlule, isantula inqubekelaphambili ebalulekile ukuze kukhiqizwe ukwakhiwa kwezicubu ze-biomimetic eziyinkimbinkimbi ze-3D.
Ngokusho kwabacwaningi baseSingapore University of Technology and Design (SUTD), iNanyang Technological University (NTU) kanye ne-Asia University, ubuchwepheshe besiko lezicubu ikakhulukazi budinga ukusheshiswa ukuze kubhekwane nebhodlela ekuvuthweni kwezicubu ze-3D ze-bioprinted multicellular ezakha izicubu ezisebenzayo. Iphepha labo locwaningo, elinesihloko esithi “Ngiphrinte isitho! Kungani singakaveli?” ishicilelwe ku-Advances in Polymer Science.
Kuleli phepha, abacwaningi baphinde banikeze ukubuyekezwa okujulile kwentuthuko yakamuva futhi bahlaziye ubuchwepheshe be-bioprinting.Inqubekelaphambili ekuthuthukisweni kwe-bioink, ukuqaliswa kwe-bioprinting entsha kanye namasu okuvuthwa kwezicubu nakho kuyahlaziywa. Kuphinde kuqashelwe indima yesayensi ye-polymer nokuthi ihambisana kanjani ne-3D bioprinting ukuze kunqobe ezinye zezithiyo ezinkulu emkhakheni wokuphrinta isitho, njengokunika amandla i-biomimetic, i-angiogenesis kanye nezakhiwo zebhayoloji ezihlobene ne-3D (njengoba izithombe ezingezansi zibonisa).
Ukusetshenziswa kwamasu ahambisanayo, njengezinhlelo eziguquguqukayo ze-co-culture perfusion, kuthathwa njengokubalulekile ukuze kuqinisekiswe ukuvuthwa nokuhlanganiswa kokwakhiwa kwezicubu ze-bioprinted. Ngisho noma manje kungenzeka ukukhiqiza izicubu zesilinganiso somuntu noma izitho ezingase zivuthwe zibe izicubu ezine-vascularized nezisebenza kancane, imboni isasele ngemuva ekunyatheliseni kwezicubu eziqondene nomuntu noma izitho ezithile ngenxa yobunkimbinkimbi be-matrix eqondene nezicubu ezithize (ECM) kanye nenqubo yokuvuthwa kwezicubu - ukuntuleka kwezinqubo zokuvuthwa kwezicubu ezihambisanayo kudinga ukusekela izinhlobo eziningi zamangqamuzana ezicubu.
"Nakuba i-3D bioprinting isesigabeni sayo sokuqala, ukugxuma okumangalisayo ekwenzile eminyakeni yamuva nje kusikisela iqiniso langempela lezitho ezitshalwe elebhu. Kodwa-ke, ukuze sifinyelele imingcele yezokwelapha, kufanele sinqobe izinselele zobuchwepheshe bokwakha izicubu. Ama-bioinks athile awaluthuthukisi inqubo yokuvuthwa kwezicubu. Lokhu ekugcineni kuzoba nomthelela omkhulu, ikusasa leziguli ezi-3 ezingancika ezimpilweni zeziguli eziningi," kusho uSolwazi D. UChua Chee Kai, umbhali ophambili wephepha.
Isengezo se-JSIsevisi yokuphrinta ye-3D nayo ibilokhu ithuthuka futhi ithuthuka, efinyelela izinga elithuthuke kakhulu embonini yezokwelapha ukuze ihlangabezane nezidingo zeziguli ezinkulu kanye nocwaningo lwesayensi. Amamodeli ethu ezokwelapha aphrintiwe e-3D nemikhiqizo eqediwe nayo isetshenziswa kabanzi ezinhlelweni zaphesheya kwezilwandle. Siyakwamukela futhi usebenzise.
