I-3D bioprinting yindawo ephezulu yokuvelisa enokuthi isetyenziswe ukuprinta izicubu kwiiseli kwaye ekugqibeleni kumalungu abalulekileyo. Oku kunokuvula ihlabathi elitsha kwezamayeza ngelixa kunceda izigulana ezifuna ukutshintshwa kwamalungu.
Endaweni yokulinda umntu onikelayo ofanelekileyo okanye abeke emngciphekweni umzimba owala ilungu lokutshintshwa, izigulana zinelungu elenzelwe injongo yokuthatha indawo yelinye elinesiphene. Nangona kunjalo, kunye nenkqubela phambili ye-3D bioprinting kule minyaka ingama-20 idlulileyo, isenayo inkqubela phambili ebalulekileyo ukuze kuveliswe i-3D ye-biomimetic tissue constructs.
Ngokutsho kwabaphandi baseSingapore University of Technology kunye noYilo (SUTD), iYunivesithi yaseNanyang Technological (NTU) kunye neYunivesithi yaseAsia, iteknoloji yenkcubeko ye-tissue ngokukodwa kufuneka ikhawuleze ukujongana ne-bottleneck ekukhuleni kwe-bioprinted multicellular 3D izicubu ezakha kwizicubu ezisebenzayo. Iphepha labo lophando, elinomxholo othi, "Ndiprintele i-organ! Kutheni singekabonakali nje?" iye yapapashwa kwi-Advances kwiPolymer Science.
Kweli phepha, abaphandi banikezela ngokuhlaziywa okunzulu kokuphuculwa kwamva nje kunye nokuhlalutya iteknoloji ye-bioprinting.Inkqubela phambili ekuphuhlisweni kwe-bioink, ukuphunyezwa kweendlela ezintsha ze-bioprinting kunye nezicwangciso zokuvuthwa kwezicubu nazo zihlalutywa. Ingqalelo ngakumbi ikwanikwa indima yenzululwazi yepolymer kunye nendlela encedisana ngayo ne-3D bioprinting ukoyisa eminye yemiqobo ephambili kwicandelo loshicilelo lwamalungu, njengokwenza i-biomimetic, i-angiogenesis kunye ne-3D enxulumene ne-anatomy-related biological structures (njengoko le mifanekiso ingezantsi ibonisa).
Ukusetyenziswa kwezicwangciso ezincedisayo, ezifana neenkqubo eziguquguqukayo ze-co-culture perfusion, kuthathwa njengento ebalulekileyo ekuqinisekiseni ukuvuthwa kunye nokuhlanganiswa kwe-bioprinted tissue builds. Nangona ngoku kunokwenzeka ukwenza izicubu zomntu okanye amalungu anokuthi avuthwe abe yi-vascularized kunye nezicubu ezisebenza ngokuyinxenye, ishishini lisahleli ngasemva kwi-bioprinting yezicubu okanye amalungu athile ngenxa yobunzima be-tissue-specific extracellular matrix (ECM) kunye nenkqubo yokuvuthwa kwezicubu-ukungabikho kolungelelwaniso lwenkcubeko ye-co-culture yangaphambili ukuxhasa iintlobo ezininzi zeeseli ze-tishu.
"Ngelixa i-3D bioprinting isekwinqanaba layo lokuqala, ukutsiba okumangalisayo ekwenzileyo kwiminyaka yakutshanje kubonisa eyona nyani yamalungu asebenzayo akhule elebhu. Nangona kunjalo, ukutyhala imida yezamayeza, kufuneka soyise imiceli mngeni yobugcisa bokwenza izicubu. Ii-bioinks ezithile aziyiphuculi inkqubo yokuvuthwa kwezicubu. Oku ekugqibeleni kuya kuba nefuthe elikhulu, ifuthe le-bioprints kwikamva le-3D yezigulane ezinokuxhomekeka kwikamva le-bioinks. UChua Chee Kai, umbhali ophambili wephepha.
JS UkongezaInkonzo yoshicilelo ye-3D iye yaphuhla ngokuqhubekayo kwaye iqhubela phambili, efikelela kwinqanaba eliphezulu kushishino lwezonyango ukuhlangabezana neemfuno zezigulane eziphambili kunye nophando lwezenzululwazi. Iimodeli zethu zonyango eziprintiweyo ze-3D kunye neemveliso ezigqityiweyo zikwasetyenziswa ngokubanzi kwizicelo zaphesheya. Wamkelekile kwaye usebenzise.
