3D bioprinting ke sethala sa tlhahiso se tsoetseng pele haholo se ka sebelisoang ho hatisa lisele tse tsoang liseleng mme qetellong litho tsa bohlokoa. Sena se ka bula lefatše le lecha la bongaka ha se ntse se tsoela bakuli molemo ka ho toba ba hlokang ho nkeloa sebaka ke litho tsa 'mele.
Ho e-na le ho emela mofani ea tšoanelehang kapa ho beha ’mele kotsing ka ho hana setho se rometsoeng, bakuli ba na le setho sa tloaelo se entsoeng ka morero ho nkela se nang le bokooa sebaka. Leha ho le joalo, leha ho na le tsoelo-pele ea 3D bioprinting lilemong tse 20 tse fetileng, e ntse e haelloa ke tsoelo-pele e kholo molemong oa ho hlahisa li-tishu tsa 3D tsa biomimetic tse rarahaneng.
Ho latela bafuputsi ba Singapore University of Technology and Design (SUTD), Nanyang Technological University (NTU) le Asia University, mahlale a setso ka ho khetheha a hloka ho potlakisoa ho sebetsana le bothata ba ho holisa lisele tse ngata tsa 3D tsa bioprinted tse hahang lithane tse sebetsang. Pampiri ea bona ea lipatlisiso, e nang le sehlooho se reng, "Nprinte organ! Ke hobane'ng ha re e-s'o hlahe?" e hatisitsoe ho Advances in Polymer Science.
Leqepheng lena, bafuputsi ba boetse ba fana ka tlhahlobo e tebileng ea ntlafatso ea morao-rao le ho hlahloba theknoloji ea bioprinting. Tsoelo-pele ea tsoelo-pele ea bioink, ts'ebetsong ea mekhoa e mecha ea ho hatisa li-bioprinting le mekhoa ea ho hōla ha lisele le tsona li hlahlojoa. Ho boetse ho hlokomelisoa haholo karolo ea mahlale a polymer le hore na e tlatselletsa 3D bioprinting ho hlola tse ling tsa litšitiso tse kholo lefapheng la khatiso ea setho, joalo ka ho nolofalletsa biomimetic, angiogenesis le 3D anatomy e amanang le sebopeho sa baeloji (joalo ka ha litšoantšo tse ka tlase li bontša).
Ts'ebeliso ea maano a tlatsetso, joalo ka litsamaiso tse matla tsa co-culture perfusion, e nkuoa e le ea bohlokoa ho netefatsa kholo le kopano ea li-bioprinted tissues. Leha hona joale ho khonahala ho etsa lisele kapa litho tsa motho tse ka holang ho ba lisele tse nang le methapo le tse sebetsang ka mokhoa o sa sebetseng, indasteri e ntse e salletse morao ho bioprinting ea lisele tse ikhethileng kapa litho tsa motho ka lebaka la ho rarahana ha matrix a extracellular (ECM) le ts'ebetso ea kholo ea lisele - khaello ea li-co-cultural media tse hlokahalang ho ts'ehetsa mefuta e mengata ea lisele.
"Le ha 3D bioprinting e ntse e le methating ea eona ea pele, ho tlola ho makatsang hoo e ho entseng lilemong tsa morao tjena ho fana ka maikutlo a 'nete ea mantlha ea litho tse holisitsoeng tsa laborateng." Leha ho le joalo, ho hatella meeli ea bongaka, re tlameha ho hlola mathata a tekheniki a ho etsa lisele. Chua Chee Kai, mongoli ea ka sehloohong oa pampiri.
JS AdditiveTs'ebeletso ea khatiso ea 3D le eona e ntse e tsoela pele ho nts'etsapele le ho hatela pele, e fihlelang boemo bo tsoetseng pele indastering ea bongaka ho fihlela litlhoko tsa bakuli ba baholo le lipatlisiso tsa mahlale. Mefuta ea rona ea bongaka e hatisitsoeng ea 3D le lihlahisoa tse feliloeng le tsona li sebelisoa haholo lits'ebetsong tsa mose ho maoatle. Rea u amohela 'me u sebelise.
