3D bioprinting ndi nsanja yapamwamba kwambiri yopanga yomwe ingagwiritsidwe ntchito kusindikiza minyewa yama cell ndipo pamapeto pake ziwalo zofunika kwambiri. Izi zitha kutsegulira maiko atsopano azachipatala pomwe zikupindulitsa mwachindunji odwala omwe amafunikira m'malo mwa chiwalo.
M'malo modikirira wopereka woyenerera kapena kuika thupi pachiswe pokana chiwalo choikidwacho, odwala amakhala ndi chiwalo chokhazikika chokhazikitsidwa ndi cholinga choloŵa m'malo chomwe chili ndi vuto. Komabe, ngakhale kupita patsogolo kwa 3D bioprinting pazaka 20 zapitazi, sikunapitebe patsogolo kwambiri kuti apange mapangidwe amtundu wa 3D biomimetic.
Malinga ndi ofufuza a Singapore University of Technology and Design (SUTD), Nanyang Technological University (NTU) ndi Asia University, matekinoloje a chikhalidwe cha minofu makamaka akuyenera kufulumizitsidwa kuti athetse vuto la kukhwima kwa 3D bioprinted multicellular tissue. Pepala lawo lofufuza, lotchedwa "Ndisindikizireni organ! Chifukwa chiyani sitinawonekere pano?" yasindikizidwa mu Advances in Polymer Science.
Mu pepala ili, ochita kafukufuku amaperekanso ndondomeko yozama ya kusintha kwaposachedwa ndikusanthula matekinoloje a bioprinting.Kupita patsogolo kwa chitukuko cha bioink, kukhazikitsidwa kwa njira zatsopano za bioprinting ndi kukhwima kwa minofu kumafufuzidwanso. Chidwi chapadera chimaperekedwanso pa ntchito ya sayansi ya polima komanso momwe imagwirizanirana ndi 3D bioprinting kuti igonjetse zopinga zina zazikulu pantchito yosindikiza ziwalo, monga kupangitsa kuti biomimetic, angiogenesis ndi 3D yokhudzana ndi chilengedwe chokhudzana ndi anatomy (monga momwe zithunzi zili pansipa zikuwonetsa).
Kugwiritsiridwa ntchito kwa njira zowonjezera, monga machitidwe amphamvu a co-culture perfusion, amaonedwa kuti ndi ofunikira kuti atsimikizire kukhwima ndi kusonkhana kwa mapangidwe a minofu ya bioprinted. Ngakhale kuti tsopano ndizotheka kupanga minyewa yamunthu kapena ziwalo zomwe zimatha kukhwima kukhala minyewa yokhazikika komanso yogwira ntchito pang'ono, makampaniwa amatsalirabe m'mbuyo pakusindikiza kwazinthu kapena ziwalo zamunthu chifukwa cha zovuta zamtundu wa extracellular matrix (ECM) ndi kukhwima kwa minyewa - kusowa kwa chikhalidwe chogwirizana ndi chikhalidwe chothandizira kuthandizira mitundu ingapo yama cell.
"Ngakhale kuti 3D bioprinting idakali koyambirira, kudumpha kodabwitsa komwe kwapanga m'zaka zaposachedwa kukuwonetsa zenizeni zenizeni za ziwalo zogwirira ntchito zomwe zakula labu. Komabe, kukankhira malire a zamankhwala, tiyenera kuthana ndi zovuta zaukadaulo pakupangira minofu. Chua Chee Kai, wolemba wamkulu wa pepalali.
Zowonjezera za JSNtchito yosindikiza ya 3D yakhala ikukula mosalekeza ndikupita patsogolo, yomwe imafika pamlingo wapamwamba kwambiri mumakampani azachipatala kuti ikwaniritse zosowa za odwala akuluakulu komanso kafukufuku wasayansi. Mitundu yathu yachipatala yosindikizidwa ya 3D ndi zinthu zomalizidwa zimagwiritsidwanso ntchito kwambiri kumayiko akunja. Takulandirani ndikugwiritsa ntchito.
