ʻO ka 3D bioprinting kahi kahua hana kiʻekiʻe loa e hiki ke hoʻohana ʻia e paʻi i nā ʻiʻo mai nā cell a me nā kino koʻikoʻi. Hiki i kēia ke wehe i nā honua hou i ka lāʻau lapaʻau ʻoiai e hoʻopōmaikaʻi pololei ana i nā poʻe maʻi e pono ai ke hoʻololi o ke kino.
Ma kahi o ka kali ʻana i kahi mea hāʻawi kūpono a i ʻole e hoʻoweliweli i ke kino e hōʻole i ke kino i hoʻololi ʻia, loaʻa i nā poʻe maʻi kahi kino maʻamau i kūkulu ʻia e hoʻololi i kahi mea kīnā. Eia nō naʻe, ʻoiai me ka holomua ʻana o ka bioprinting 3D i nā makahiki he 20 i hala iho nei, ʻaʻole naʻe i ka holomua nui i mea e hana ai i nā mea kikoo biomimetic 3D paʻakikī.
Wahi a nā mea noiʻi ma Singapore University of Technology and Design (SUTD), Nanyang Technological University (NTU) a me Asia University, pono e hoʻonui ʻia nā ʻenehana moʻomeheu kikoʻī e hoʻoponopono ai i ka bottleneck i ke kūkulu ʻana i nā ʻiʻo 3D multicellular bioprinted i loko o nā kiko hana. ʻO kā lākou pepa noiʻi, i kapa ʻia "E paʻi iaʻu i kahi ʻoka! No ke aha mākou i hōʻike ʻole ai?" ua paʻi ʻia ma Advances in Polymer Science.
Ma kēia pepa, hāʻawi pū nā mea noiʻi i kahi loiloi hohonu o nā hoʻomaikaʻi hou ʻana a me ka nānā ʻana i nā ʻenehana bioprinting. ʻO ka holomua o ka hoʻomohala bioink, ka hoʻokō ʻana i nā hoʻolālā bioprinting hou a me nā hoʻolālā o ke kino. Hāʻawi ʻia ka manaʻo nui i ke kuleana o ka ʻepekema polymer a pehea e hoʻokō ai i ka paʻi bio 3D e lanakila ai i kekahi o nā pilikia nui ma ke ʻano o ka paʻi ʻana, e like me ka hiki ʻana i ka biomimetic, angiogenesis a me 3D anatomy-related biological structures (e like me nā kiʻi ma lalo nei).
ʻO ka hoʻohana ʻana i nā hoʻolālā hoʻohui, e like me ka dynamic co-culture perfusion system, i manaʻo ʻia he mea nui e hōʻoia i ka oʻo ʻana a me ka hui ʻana o nā mea hana bioprinted. ʻOiai hiki i kēia manawa ke hana i nā ʻiʻo a i ʻole nā mea kino kanaka i oʻo i loko o nā ʻiʻo vascularized a me nā ʻāpana hana, ke waiho mau nei ka ʻoihana i ka bioprinting o nā ʻiʻo a i ʻole nā mea kikoʻī o ke kanaka ma muli o ka paʻakikī o ka tissue-specific extracellular matrix (ECM) a me ke kaʻina maturation kiko - ʻaʻole pono ka media co-culture kūpono e kākoʻo i nā ʻano cell he nui.
"ʻOiai ʻo ka 3D bioprinting i kona wā mua, ʻo nā leʻaleʻa kupaianaha i hana ʻia i nā makahiki i hala iho nei e hōʻike ana i ka ʻoiaʻiʻo loa o nā kino hana i ulu ʻia e lab-grown. bioprinting," wahi a Polofesa Chua Chee Kai, ka mea kākau alakaʻi o ka pepa.
JS HoʻohuiKe ulu mau nei ka lawelawe paʻi 3D a me ka holomua, a hiki i kahi pae kiʻekiʻe i ka ʻoihana lapaʻau e hoʻokō i nā pono o nā maʻi nui a me ka noiʻi ʻepekema. Hoʻohana nui ʻia kā mākou mau hiʻohiʻona lapaʻau paʻi 3D a me nā huahana i hoʻopau ʻia i nā noi ma waho. Aloha a hoʻohana.
